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MDMA – Ecstasy Overview
MDMA (3-4 methylenedioxymethamphetamine) is a synthetic, psychoactive drug with a chemical structure similar to the stimulant methamphetamine and the hallucinogen mescaline. MDMA is an illegal drug that acts as both a stimulant and psychedelic, producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile experiences. It is known commonly as Ecstasy and Molly.
MDMA exerts its primary effects in the brain on neurons that use the chemicals serotonin, dopamine and norepinephrine to communicate with other neurons. Serotonin is most likely responsible for the feelings of empathy, elevated mood, and emotional closeness experienced with this drug.
Overall, these neurotransmitter systems play an important role in regulating: mood, energy/activity and the reward system, appetite, aggression, sexual activity, sleep, sensitivity to pain, heart rate, blood pressure. MDMA is most often available in tablet or capsule form and is usually ingested orally. Ecstasy traffickers consistently use brand names and logos as marketing tools and to distinguish their product from that of competitors. It is also available as a powder and is sometimes snorted, taken as a liquid, and it is occasionally smoked but rarely injected.
This drug is often considered the drug of choice within the rave culture and is also used at clubs, festivals, and house parties. In the rave environment, the sensory effects of music and lighting are often highly synergistic with the drug. The psychedelic amphetamine quality of MDMA offers multiple appealing aspects to users in the rave setting. Some users enjoy the feeling of mass communion from the inhibition-reducing effects of the drug, while others use it as party fuel because of the drug’s stimulatory effects.
MDMA use was also combined with psychotherapy sessions. A month after the second session, a greater percentage in the high-dose groups no longer met diagnostic criteria for PTSD, compared with the low-dose group.
Almost 60% of people who use ecstasy report withdrawal symptoms, including: fatigue, loss of appetite, depressed feelings, trouble concentrating. Research in animals indicates that this drug, also referred to as MDMA or Molly, is neurotoxic; whether or not this is also true in humans is under investigation. It’s effect on cognition and memory is a concern. The drug can also be lethal on rare occasions.
MDMA is used less often than other stimulants, typically less than once per week. Researchers gave three different doses of MDMA to 22 veterans, three firefighters and one police officer with PTSD. Among the participants, 23% had used ecstasy before.
In general, for some people, this illicit drug can be addictive. MDMA users report feeling the onset of subjective effects within 30 to 60 minutes of oral consumption and reaching peak effect at 75 to 120 minutes, which then plateaus for about 3.5 hours. A survey of young adult and adolescent users found that 43% met the accepted diagnostic criteria for dependence, as evidenced by continued use despite knowledge of physical or psychological harm, withdrawal effects, and tolerance (or diminished response), and 34% met the criteria for drug abuse.
In high doses, ecstasy can interfere with the body’s ability to regulate temperature. On rare but unpredictable occasions, this can lead to a sharp increase in body temperature (hyperthermia), resulting in liver, kidney, and cardiovascular system failure, and death. The desired short-term psychoactive effects of MDMA have been reported to include: Euphoria – a sense of general well-being and happiness, Increased self-confidence, sociability, and perception of facilitated communication, A sense of inner peace, Mild hallucination, Enhanced sensation, perception, or sexuality, Altered sense of time. Psychological effects can include confusion, depression, sleep problems, drug craving, and severe anxiety. These problems can occur during and for days or weeks after taking ecstasy.
In case of overdose and a serious symptoms such as passing out or trouble breathing, give or take naloxone if available, then dial police or emmergencies’ number. If the person is awake and has no symptoms, call a poison control center right away.
MISUSE OF MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.