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Pharmacodynamics and pharmacokinetics of Rohypnol
Pharmacodynamics of Rohypnol
Rohypnol (Flunitrazepam) is a tranquilizer of benzodiazepine series. Some tranquilizers of the benzodiazepine group (“small tranquilizers”) have a pronounced hypnotic effect and effectively eliminate sleep disorders. They are called hypnotic tranquilizers.
One of them is Rohypnol, so it is often referred to as sleeping pills. It shortens the period of falling asleep – sleeping pills come quickly to buy here (after 20-40 minutes) and lasts about 8 hours. At the same time, the phases of sleep are not disturbed, and the number of awakenings at night decreases.
As a true tranquilizer, Rohypnol has an anxiolytic effect, which manifests itself in reducing tension, eliminating anxiety, fear and anxiety. In this regard, benzodiazepines are often prescribed for insomnia, which is associated with an anxiety state or stressful situation. In addition, Rohypnol (Flunitrazepam) has an anticonvulsant and muscle relaxant effect. Productive symptoms (delusional and hallucinatory disorders) are not affected.
Pharmacokinetics of Rohypnol
Rohypnol is well absorbed from the digestive tract. After taking 1 mg of the drug, Cmax is achieved after 1-2 hours. Bioavailability is 70-90%. Food reduces the rate of absorption. Moderate cumulation with daily use is noted. The equilibrium concentration of flunitrazepam is established after 5 days. It penetrates well into the cerebrospinal fluid and into breast milk. The metabolism process occurs in the liver.
Indications for use
- Falling asleep;
- Manic-depressive states;
- Schizophrenia (in complex treatment);
- Withdrawal syndrome with alcoholism;
- Premedication before anesthesia and induction anesthesia.
- Myasthenia gravis;
- Hypersensitivity to benzodiazepines;
- Liver or kidney failure;
- Poisoning with alcohol, antidepressants, antipsychotics and sleeping pills;
- Chronic alcoholism;
- Intake with MAO inhibitors;
- Respiratory failure (decompensation);
- Pregnancy, breastfeeding;
- Newborns and early childhood.
- C caution is prescribed for cerebrovascular accidents, in old age, with sleep apnea.
Side effects of Rohypnol
- Headache, fatigue, slowing of mental reactions, weakness, epileptic seizures, amnesia, disorientation in space
- Upon waking, the appearance of hallucinations, agitation;
- Dyspeptic symptoms;
- Difficulty breathing
- Skin rash;
- Decrease in blood pressure;
- Change in libido;
- Urinary retention;
- Upon cancellation – sleep disturbances.
Instructions (Method and dosage)
In case of sleep disorders, inside, 20 minutes before sleep, 1-2 mg for adults. Elderly – from 0.5 to 2 mg. Adolescents under 15 years of age – 0.5-1.5 mg. The duration of treatment is from 2-5 days to 3 weeks, taking into account the gradual reduction in dose. In children, much less.
For sedation, Rohypnol is administered in oil 30 minutes before general anesthesia. With the introduction of anesthesia is introduced in / in 1-2 mg. During the operation, small doses are administered to maintain general anesthesia.
Symptoms are manifested: confusion, ataxia, drowsiness, severe muscle weakness, hypotension, respiratory depression. Perhaps the development of coma and death.
Treatment is being undertaken: induce vomiting, rinse the stomach, take sorbents, monitor cardiac activity and respiratory function. In a hospital, the introduction of flumazenil (an antagonist of benzodiazepine receptors).
Kindly do not share this medication with others. Sharing it is against the law.
When combined with barbiturates, tranquilizers, antidepressants, antipsychotics and other drugs that depress the central nervous system, this effect is enhanced. A similar reaction is caused by alcohol intake. Rohypnol potentiates the effect of muscle relaxants. Inhibitors of microsomal liver enzymes enhance the effects of the drug. Aminophylline has an antagonistic effect against the tranquilizing and hypnotic effects of Rogipnol. The risk of drug dependence increases significantly with the use of other sleeping pills and psychotropic drugs.
Rohypnol is available as an olive-green or white pill. Most users use the drug by crushing the pills and snorting the powder, sprinkling it on weed and smoking it, dissolving it in a drink or injecting it.
MISUSE OF Benzodiazepine MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.